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Hepatic ischemia-reperfusion impairs blood-brain barrier partly due to release of arginase from injured liver

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Ta A, Caudle AS, Hayes-Jordan A, Lai S, Mehran RJ, Moon BS, Prabhu SS, Reece G, Schmeler KM, Skibber JM, Ward JF, Chemaly RF, Anderson JJ, Segal C, Ca P, Fleming JB, Swisher SG , Levenback CF

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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11